Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology

Cytochrome P450, family 3, subfamily A (CYP3A) enzymes metabolize approximately 50% of commercially available drugs. Recently, we developed fully humanized transchromosomic (Tc) CYP3A mice with the CYP3A cluster including CYP3A4, CYP3A5, CYP3A7, and CYP3A43. Our humanized CYP3A mice have the CYP3A5*...

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Vydáno v:Sci Rep
Hlavní autoři: Abe, Satoshi, Kobayashi, Kaoru, Oji, Asami, Sakuma, Tetsushi, Kazuki, Kanako, Takehara, Shoko, Nakamura, Kazuomi, Okada, Azusa, Tsukazaki, Yasuko, Senda, Naoto, Honma, Kazuhisa, Yamamoto, Takashi, Ikawa, Masahito, Chiba, Kan, Oshimura, Mitsuo, Kazuki, Yasuhiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680201/
https://ncbi.nlm.nih.gov/pubmed/29123154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15033-0
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