miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

B cell development is a tightly regulated process dependent on sequential rearrangements of immunoglobulin loci that encode the antigen receptor. To elucidate the role of microRNAs (miRNAs) in the orchestration of B cell development, we ablated all miRNAs at the earliest stage of B cell development...

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Detalhes bibliográficos
Publicado no:Cell Rep
Principais autores: Coffre, Maryaline, Benhamou, David, Rieß, David, Blumenberg, Lili, Snetkova, Valentina, Hines, Marcus J., Chakraborty, Tirtha, Bajwa, Sofia, Jensen, Kari, Chong, Mark M.W., Getu, Lelise, Silverman, Gregg J., Blelloch, Robert, Littman, Dan R., Calado, Dinis, Melamed, Doron, Skok, Jane A., Rajewsky, Klaus, Koralov, Sergei B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679080/
https://ncbi.nlm.nih.gov/pubmed/27880903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.006
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