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Antibody repertoire deep sequencing reveals antigen-independent selection in maturing B cells
Antibody repertoires are known to be shaped by selection for antigen binding. Unexpectedly, we now show that selection also acts on a non–antigen-binding antibody region: the heavy-chain variable (V(H))–encoded “elbow” between variable and constant domains. By sequencing 2.8 million recombined heavy...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078805/ https://ncbi.nlm.nih.gov/pubmed/24927543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403278111 |
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