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Antibody repertoire deep sequencing reveals antigen-independent selection in maturing B cells

Antibody repertoires are known to be shaped by selection for antigen binding. Unexpectedly, we now show that selection also acts on a non–antigen-binding antibody region: the heavy-chain variable (V(H))–encoded “elbow” between variable and constant domains. By sequencing 2.8 million recombined heavy...

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Main Authors: Kaplinsky, Joseph, Li, Anthony, Sun, Amy, Coffre, Maryaline, Koralov, Sergei B., Arnaout, Ramy
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078805/
https://ncbi.nlm.nih.gov/pubmed/24927543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403278111
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