Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

PURPOSE: Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination...

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Dettagli Bibliografici
Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Roy Chowdhury, Uttio, Rinkoski, Tommy A., Bahler, Cindy K., Millar, J. Cameron, Bertrand, Jacques A., Holman, Bradley H., Sherwood, Joseph M., Overby, Darryl R., Stoltz, Kristen L., Dosa, Peter I., Fautsch, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2017
Soggetti:
Glaucoma
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678549/
https://ncbi.nlm.nih.gov/pubmed/29114841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22538
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