Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

PURPOSE: Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Roy Chowdhury, Uttio, Rinkoski, Tommy A., Bahler, Cindy K., Millar, J. Cameron, Bertrand, Jacques A., Holman, Bradley H., Sherwood, Joseph M., Overby, Darryl R., Stoltz, Kristen L., Dosa, Peter I., Fautsch, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2017
Assuntos:
Glaucoma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678549/
https://ncbi.nlm.nih.gov/pubmed/29114841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22538
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