Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

PURPOSE: Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Roy Chowdhury, Uttio, Rinkoski, Tommy A., Bahler, Cindy K., Millar, J. Cameron, Bertrand, Jacques A., Holman, Bradley H., Sherwood, Joseph M., Overby, Darryl R., Stoltz, Kristen L., Dosa, Peter I., Fautsch, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2017
Témata:
Glaucoma
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678549/
https://ncbi.nlm.nih.gov/pubmed/29114841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22538
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