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Analogs of the ATP-Sensitive Potassium (K(ATP)) Channel Opener Cromakalim with in Vivo Ocular Hypotensive Activity

K(ATP) channel openers have emerged as potential therapeutics for the treatment of glaucoma, lowering intraocular pressure in animal models and cultured human anterior segments. We have prepared water soluble phosphate and dipeptide derivatives of the K(ATP) channel opener cromakalim and evaluated t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Med Chem
Prif Awduron: Chowdhury, Uttio Roy, Viker, Kimberly B., Stoltz, Kristen L., Holman, Bradley H., Fautsch, Michael P., Dosa, Peter I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567990/
https://ncbi.nlm.nih.gov/pubmed/27367033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00406
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