Analogs of the ATP-Sensitive Potassium (K(ATP)) Channel Opener Cromakalim with in Vivo Ocular Hypotensive Activity

K(ATP) channel openers have emerged as potential therapeutics for the treatment of glaucoma, lowering intraocular pressure in animal models and cultured human anterior segments. We have prepared water soluble phosphate and dipeptide derivatives of the K(ATP) channel opener cromakalim and evaluated t...

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Vydáno v:J Med Chem
Hlavní autoři: Chowdhury, Uttio Roy, Viker, Kimberly B., Stoltz, Kristen L., Holman, Bradley H., Fautsch, Michael P., Dosa, Peter I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567990/
https://ncbi.nlm.nih.gov/pubmed/27367033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00406
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