Analogs of the ATP-Sensitive Potassium (K(ATP)) Channel Opener Cromakalim with in Vivo Ocular Hypotensive Activity

K(ATP) channel openers have emerged as potential therapeutics for the treatment of glaucoma, lowering intraocular pressure in animal models and cultured human anterior segments. We have prepared water soluble phosphate and dipeptide derivatives of the K(ATP) channel opener cromakalim and evaluated t...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Chowdhury, Uttio Roy, Viker, Kimberly B., Stoltz, Kristen L., Holman, Bradley H., Fautsch, Michael P., Dosa, Peter I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567990/
https://ncbi.nlm.nih.gov/pubmed/27367033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00406
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