Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates

Purpose: To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. Methods: Optimal CKLP1 concentration was determined by dose response and utilized in short- (5–8 days) and long-term (60 days) evaluation in hound dogs...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Ocul Pharmacol Ther
Main Authors: Roy Chowdhury, Uttio, Kudgus, Rachel A., Holman, Bradley H., Rinkoski, Tommy A., Hann, Cheryl R., Bahler, Cindy K., McCloud, Eric, Appt, Susan E., Reid, Joel M., Dosa, Peter I., Fautsch, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215408/
https://ncbi.nlm.nih.gov/pubmed/33784195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2020.0137
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados