Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates

Purpose: To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. Methods: Optimal CKLP1 concentration was determined by dose response and utilized in short- (5–8 days) and long-term (60 days) evaluation in hound dogs...

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Publicado en:J Ocul Pharmacol Ther
Autores principales: Roy Chowdhury, Uttio, Kudgus, Rachel A., Holman, Bradley H., Rinkoski, Tommy A., Hann, Cheryl R., Bahler, Cindy K., McCloud, Eric, Appt, Susan E., Reid, Joel M., Dosa, Peter I., Fautsch, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc., publishers 2021
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215408/
https://ncbi.nlm.nih.gov/pubmed/33784195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2020.0137
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