Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates

Purpose: To evaluate pharmacokinetic parameters and ocular hypotensive effects of cromakalim prodrug 1 (CKLP1) in normotensive large animal models. Methods: Optimal CKLP1 concentration was determined by dose response and utilized in short- (5–8 days) and long-term (60 days) evaluation in hound dogs...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Ocul Pharmacol Ther
Asıl Yazarlar: Roy Chowdhury, Uttio, Kudgus, Rachel A., Holman, Bradley H., Rinkoski, Tommy A., Hann, Cheryl R., Bahler, Cindy K., McCloud, Eric, Appt, Susan E., Reid, Joel M., Dosa, Peter I., Fautsch, Michael P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc., publishers 2021
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215408/
https://ncbi.nlm.nih.gov/pubmed/33784195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2020.0137
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller