Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits

Elevated intraocular pressure is the only treatable risk factor for glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide. We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium channel opener, as a new ocular hypotensive agent...

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Publicado en:PLoS One
Autores principales: Roy Chowdhury, Uttio, Kudgus, Rachel A., Rinkoski, Tommy A., Holman, Bradley H., Bahler, Cindy K., Hann, Cheryl R., Reid, Joel M., Dosa, Peter I., Fautsch, Michael P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162492/
https://ncbi.nlm.nih.gov/pubmed/32298376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231841
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