Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits

Elevated intraocular pressure is the only treatable risk factor for glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide. We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium channel opener, as a new ocular hypotensive agent...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Roy Chowdhury, Uttio, Kudgus, Rachel A., Rinkoski, Tommy A., Holman, Bradley H., Bahler, Cindy K., Hann, Cheryl R., Reid, Joel M., Dosa, Peter I., Fautsch, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162492/
https://ncbi.nlm.nih.gov/pubmed/32298376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231841
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