Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells

Evidence suggests that nonsteroidal anti-inflammatory drug aspirin (acetylsalicylic acid) may improve patient survival in PIK3CA-mutant colorectal carcinoma, but not in PIK3CA-wild-type carcinoma. However, whether aspirin directly influences the viability of PIK3CA-mutant colon cancer cells is poorl...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Gu, Mancang, Nishihara, Reiko, Chen, Yang, Li, Wanwan, Shi, Yan, Masugi, Yohei, Hamada, Tsuyoshi, Kosumi, Keisuke, Liu, Li, da Silva, Annacarolina, Nowak, Jonathan A., Twombly, Tyler, Du, Chunxia, Koh, Hideo, Li, Wenbin, Meyerhardt, Jeffrey A., Wolpin, Brian M., Giannakis, Marios, Aguirre, Andrew J., Bass, Adam J., Drew, David A., Chan, Andrew T., Fuchs, Charles S., Qian, Zhi Rong, Ogino, Shuji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675640/
https://ncbi.nlm.nih.gov/pubmed/29152088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20972
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