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Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation

Many cell signaling events are coordinated by intrinsically disordered protein regions (IDRs) that undergo multisite Serine/Threonine phosphorylation. The conformational properties of these IDRs prior to and following multi-site phosphorylation are directly relevant to understanding their functions....

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Martin, Erik W., Holehouse, Alex S., Grace, Christy R., Hughes, Alex, Pappu, Rohit V., Mittag, Tanja
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675102/
https://ncbi.nlm.nih.gov/pubmed/27807972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b10272
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