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Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
Prion-like domains (PLDs) can drive liquid-liquid phase separation (LLPS) in cells. Using an integrative biophysical approach that includes NMR, SAXS and multiscale simulations we have uncovered sequence features that determine the overall phase behavior of PLDs. We find that the numbers (valence) o...
में बचाया:
| में प्रकाशित: | Science |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7297187/ https://ncbi.nlm.nih.gov/pubmed/32029630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw8653 |
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