Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

Prion-like domains (PLDs) can drive liquid-liquid phase separation (LLPS) in cells. Using an integrative biophysical approach that includes NMR, SAXS and multiscale simulations we have uncovered sequence features that determine the overall phase behavior of PLDs. We find that the numbers (valence) o...

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Publicado en:Science
Main Authors: Martin, Erik W., Holehouse, Alex S., Peran, Ivan, Farag, Mina, Incicco, J. Jeremias, Bremer, Anne, Grace, Christy R., Soranno, Andrea, Pappu, Rohit V., Mittag, Tanja
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297187/
https://ncbi.nlm.nih.gov/pubmed/32029630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw8653
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