The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells

Actomyosin stress fibers impinge on the nucleus and can exert compressive forces on it. These compressive forces have been proposed to elongate nuclei in fibroblasts, and lead to abnormally shaped nuclei in cancer cells. In these models, the elongated or flattened nuclear shape is proposed to store...

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Bibliographic Details
Published in:J Cell Physiol
Main Authors: Tocco, Vincent J., Li, Yuan, Christopher, Keith G., Matthews, James H., Aggarwal, Varun, Paschall, Lauren, Luesch, Hendrik, Licht, Jonathan D., Dickinson, Richard B., Lele, Tanmay P.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673577/
https://ncbi.nlm.nih.gov/pubmed/28542912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26031
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