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Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response to the binding of a neurotransmitter. Despite the increasing availability of high-resolution structures of pLGICs, a detailed understanding of the functional i...
Uloženo v:
| Vydáno v: | PLoS Comput Biol |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5673239/ https://ncbi.nlm.nih.gov/pubmed/29069080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005784 |
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