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Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics

Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response to the binding of a neurotransmitter. Despite the increasing availability of high-resolution structures of pLGICs, a detailed understanding of the functional i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Comput Biol
Egile Nagusiak: Martin, Nicolas E, Malik, Siddharth, Calimet, Nicolas, Changeux, Jean-Pierre, Cecchini, Marco
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673239/
https://ncbi.nlm.nih.gov/pubmed/29069080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005784
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