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Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics.
Pentameric ligand-gated ion channels (pLGICs) mediate intercellular communication at synapses through the opening of an ion pore in response to the binding of a neurotransmitter. Despite the increasing availability of high-resolution structures of pLGICs, a detailed understanding of the functional i...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science (PLoS)
2017-10-01
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| Серии: | PLoS Computational Biology |
| Online-ссылка: | http://europepmc.org/articles/PMC5673239?pdf=render |
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