Φορτώνει......
Mutagenic Replication of N(2)-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase I and Sulfolobus solfataricus DNA Polymerase IV
Benzo[a]pyrene, a potent human carcinogen, is metabolized in vivo to a diol epoxide that reacts with the N(2)-position of guanine to produce N(2)-BP-dG adducts. These adducts are mutagenic causing G to T transversions. These adducts block replicative polymerases but can be bypassed by the Y-family t...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Chem Res Toxicol |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5673090/ https://ncbi.nlm.nih.gov/pubmed/28402640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00466 |
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