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Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease

Niemann-Pick type C (NPC) disease is an inherited, progressive neurodegenerative disorder principally caused by mutations in the NPC1 gene. NPC disease is characterized by the accumulation of unesterified cholesterol in the late endosomes (LE) and lysosomes (Ly) (LE/Ly). Vorinostat, a histone deacet...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Subramanian, Kanagaraj, Rauniyar, Navin, Lavalleé-Adam, Mathieu, Yates, John R., Balch, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672001/
https://ncbi.nlm.nih.gov/pubmed/28860124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.064949
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