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Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer
Deregulation and activation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin (mTOR) pathway have a major role in proliferation and cell survival in breast cancer. However, as single agents, mTOR inhibitors have had modest antitumor efficacy. In this study, w...
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| Veröffentlicht in: | Oncogenesis |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5668884/ https://ncbi.nlm.nih.gov/pubmed/28991258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.86 |
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