Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors

There is limited data on co-expression of FGFR/FGR amplifications and PI3K/ AKT/mTOR alterations in breast cancer. Tumors from patients with metastatic breast cancer referred to our Phase I Program were analyzed by next generation sequencing (NGS). Genomic libraries were selected for all exons of 23...

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Bibliografische gegevens
Gepubliceerd in:Oncoscience
Hoofdauteurs: Wheler, Jennifer J., Atkins, Johnique T., Janku, Filip, Moulder, Stacy L., Stephens, Philip J., Yelensky, Roman, Valero, Vicente, Miller, Vincent, Kurzrock, Razelle, Meric-Bernstam, Funda
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965259/
https://ncbi.nlm.nih.gov/pubmed/27489863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncoscience.307
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