A common variant of IL-6R is associated with elevated IL-6 pathway activity in Alzheimer’s disease brains

The common p.D358A variant (rs2228145) in IL-6R is associated with risk for multiple diseases and with increased levels of soluble IL-6R in the periphery and central nervous system (CNS). Here, we show that the p.D358A allele leads to increased proteolysis of membrane bound IL-6R and demonstrate tha...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Haddick, Patrick C.G., Larson, Jessica L., Rathore, Nisha, Bhangale, Tushar R., Phung, Qui T., Srinivasan, Karpagam, Hansen, David V., Lill, Jennie R., Pericak-Vance, Margaret A., Haines, Jonathan, Farrer, Lindsay A., Kauwe, John S., Schellenberg, Gerard D., Cruchaga, Carlos, Goate, Alison M., Behrens, Timothy W., Watts, Ryan J., Graham, Robert R., Kaminker, Joshua S., van der Brug, Marcel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667357/
https://ncbi.nlm.nih.gov/pubmed/28106546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160524
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