A rare mutation in UNC5C predisposes to Alzheimer’s disease and increases neuronal cell death

We have identified a rare coding mutation, T835M (rs137875858), in the Netrin receptor UNC5C that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer’s disease (LOAD), and was associated with disease across four large case/control cohorts (OR =...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Wetzel-Smith, MK, Hunkapiller, J, Bhangale, TR, Srinivasan, K, Maloney, JA, Atwal, JK, Sa, SM, Yaylaoglu, MB, Foreman, O, Ortmann, W, Rathore, N, Hansen, DV, Tessier-Lavigne, M, Mayeux, R, Pericak-Vance, M, Haines, J, Farrer, LA, Schellenberg, GD, Goate, A, Behrens, TW, Cruchaga, C, Watts, RJ, Graham, RR
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301587/
https://ncbi.nlm.nih.gov/pubmed/25419706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3736
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