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A rare mutation in UNC5C predisposes to Alzheimer’s disease and increases neuronal cell death
We have identified a rare coding mutation, T835M (rs137875858), in the Netrin receptor UNC5C that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer’s disease (LOAD), and was associated with disease across four large case/control cohorts (OR =...
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| Publicado no: | Nat Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301587/ https://ncbi.nlm.nih.gov/pubmed/25419706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3736 |
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