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Atrial-ventricular differences in rabbit cardiac voltage-gated Na(+) currents: Basis for atrial-selective block by ranolazine
BACKGROUND: Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a risk of ventricular tachyarrhythmia. The antianginal agent ranolazine is a prototypic atrial-selective voltage-gated Na(+) channel blocker but the mecha...
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| Publicat a: | Heart Rhythm |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5666337/ https://ncbi.nlm.nih.gov/pubmed/28610990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2017.06.012 |
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