Inhibition of voltage-gated Na(+) currents by eleclazine in rat atrial and ventricular myocytes

BACKGROUND: Atrial-ventricular differences in voltage-gated Na(+) currents might be exploited for atrial-selective antiarrhythmic drug action for the suppression of atrial fibrillation without risk of ventricular tachyarrhythmia. Eleclazine (GS-6615) is a putative antiarrhythmic drug with properties...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Heart Rhythm O2
Hauptverfasser: Caves, Rachel E., Carpenter, Alexander, Choisy, Stéphanie C., Clennell, Ben, Cheng, Hongwei, McNiff, Cameron, Mann, Brendan, Milnes, James T., Hancox, Jules C., James, Andrew F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Experimental
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442036/
https://ncbi.nlm.nih.gov/pubmed/32864638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hroo.2020.05.006
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