Atrial-ventricular differences in rabbit cardiac voltage-gated Na(+) currents: Basis for atrial-selective block by ranolazine

BACKGROUND: Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a risk of ventricular tachyarrhythmia. The antianginal agent ranolazine is a prototypic atrial-selective voltage-gated Na(+) channel blocker but the mecha...

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Detalhes bibliográficos
Publicado no:Heart Rhythm
Main Authors: Caves, Rachel E., Cheng, Hongwei, Choisy, Stéphanie C., Gadeberg, Hanne C., Bryant, Simon M., Hancox, Jules C., James, Andrew F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666337/
https://ncbi.nlm.nih.gov/pubmed/28610990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2017.06.012
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