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Differential responses of rabbit ventricular and atrial transient outward current (I(to)) to the I(to) modulator NS5806

Transient outward potassium current (I(to)) in the heart underlies phase 1 repolarization of cardiac action potentials and thereby affects excitation–contraction coupling. Small molecule activators of I(to) may therefore offer novel treatments for cardiac dysfunction, including heart failure and atr...

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Pubblicato in:Physiol Rep
Autori principali: Cheng, Hongwei, Cannell, Mark B., Hancox, Jules C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350179/
https://ncbi.nlm.nih.gov/pubmed/28270595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13172
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