Persistent detection of alternatively spliced BCR‐ABL variant results in a failure to achieve deep molecular response

Treatment with tyrosine kinase inhibitors (TKI) may sequentially induce TKI‐resistant BCR‐ABL mutants in chronic myeloid leukemia (CML). Conventional PCR monitoring of BCR‐ABL is an important indicator to determine therapeutic intervention for preventing disease progression. However, PCR cannot sepa...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Yuda, Junichiro, Miyamoto, Toshihiro, Odawara, Jun, Ohkawa, Yasuyuki, Semba, Yuichiro, Hayashi, Masayasu, Miyamura, Koichi, Tanimoto, Mitsune, Yamamoto, Kazuhito, Taniwaki, Masafumi, Akashi, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666036/
https://ncbi.nlm.nih.gov/pubmed/28801986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13353
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