Proteomic alterations associated with biomechanical dysfunction are early processes in the Emilin1 deficient mouse model of aortic valve disease

Aortic valve (AV) disease involves stiffening of the AV cusp with progression characterized by inflammation, fibrosis, and calcification. Here, we examine the relationship between biomechanical valve function and proteomic changes before and after the development of AV pathology in the Emilin1−/− mo...

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Dettagli Bibliografici
Pubblicato in:Ann Biomed Eng
Autori principali: Angel, PM, Narmoneva, DA, Sewell-Loftin, MK, Munjal, C, Dupuis, L, Landis, BJ, Jegga, A, Kern, CB, Merryman, WD, Baldwin, HS, Bressan, GM, Hinton, RB
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665708/
https://ncbi.nlm.nih.gov/pubmed/28812215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10439-017-1899-0
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