Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis

Aortic valve disease is a burgeoning public health problem associated with significant mortality. Loss of function mutations in NOTCH1 cause bicuspid aortic valve (BAV) and calcific aortic valve disease. Because calcific nodules manifest on the fibrosa side of the cusp in low fluidic oscillatory she...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cardiovasc Dev Dis
Prif Awduron: Godby, Richard C., Munjal, Charu, Opoka, Amy M., Smith, J. Michael, Yutzey, Katherine E., Narmoneva, Daria A., Hinton, Robert B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856658/
https://ncbi.nlm.nih.gov/pubmed/29552567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcdd1030237
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