Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis

Aortic valve disease is a burgeoning public health problem associated with significant mortality. Loss of function mutations in NOTCH1 cause bicuspid aortic valve (BAV) and calcific aortic valve disease. Because calcific nodules manifest on the fibrosa side of the cusp in low fluidic oscillatory she...

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Detalles Bibliográficos
Publicado en:J Cardiovasc Dev Dis
Main Authors: Godby, Richard C., Munjal, Charu, Opoka, Amy M., Smith, J. Michael, Yutzey, Katherine E., Narmoneva, Daria A., Hinton, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856658/
https://ncbi.nlm.nih.gov/pubmed/29552567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcdd1030237
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