Polygenic determinants in extremes of high-density lipoprotein cholesterol

HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect genetic variants. In a discovery cohort of 255 u...

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Vydáno v:J Lipid Res
Hlavní autoři: Dron, Jacqueline S., Wang, Jian, Low-Kam, Cécile, Khetarpal, Sumeet A., Robinson, John F., McIntyre, Adam D., Ban, Matthew R., Cao, Henian, Rhainds, David, Dubé, Marie-Pierre, Rader, Daniel J., Lettre, Guillaume, Tardif, Jean-Claude, Hegele, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2017
Témata:
Patient-Oriented and Epidemiological Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665671/
https://ncbi.nlm.nih.gov/pubmed/28870971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M079822
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