Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials

OBJECTIVE: To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders. METHODS: Individual participant data were obtained from 3 randomized trials in...

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Published in:Neurology
Main Authors: van Eijk, Ruben P.A., Jones, Ashley R., Sproviero, William, Shatunov, Aleksey, Shaw, Pamela J., Leigh, P. Nigel, Young, Carolyn A., Shaw, Christopher E., Mora, Gabriele, Mandrioli, Jessica, Borghero, Giuseppe, Volanti, Paolo, Diekstra, Frank P., van Rheenen, Wouter, Verstraete, Esther, Eijkemans, Marinus J.C., Veldink, Jan H., Chio, Adriano, Al-Chalabi, Ammar, van den Berg, Leonard H., van Es, Michael A.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664299/
https://ncbi.nlm.nih.gov/pubmed/28978660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000004606
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