Mitochondrial DNA depletion, mitochondrial mutations and high TFAM expression in hepatocellular carcinoma

We investigated the role of mitochondrial genetic alterations in hepatocellular carcinoma by directly comparing the mitochondrial genomes of 86 matched pairs of HCC and non-tumor liver samples. Substitutions in 637 mtDNA sites were detected, comprising 89.80% transitions and 6.60% transversions. For...

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Vydáno v:Oncotarget
Hlavní autoři: Qiao, Lihua, Ru, Guoqing, Mao, Zhuochao, Wang, Chenghui, Nie, Zhipeng, Li, Qiang, Huang-yang, Yiyi, Zhu, Ling, Liang, Xiaoyang, Yu, Jialing, Jiang, Pingping
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663603/
https://ncbi.nlm.nih.gov/pubmed/29137431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21033
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