Mitochondrial DNA depletion, mitochondrial mutations and high TFAM expression in hepatocellular carcinoma

We investigated the role of mitochondrial genetic alterations in hepatocellular carcinoma by directly comparing the mitochondrial genomes of 86 matched pairs of HCC and non-tumor liver samples. Substitutions in 637 mtDNA sites were detected, comprising 89.80% transitions and 6.60% transversions. For...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Qiao, Lihua, Ru, Guoqing, Mao, Zhuochao, Wang, Chenghui, Nie, Zhipeng, Li, Qiang, Huang-yang, Yiyi, Zhu, Ling, Liang, Xiaoyang, Yu, Jialing, Jiang, Pingping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663603/
https://ncbi.nlm.nih.gov/pubmed/29137431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21033
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