Mitochondrial DNA depletion, mitochondrial mutations and high TFAM expression in hepatocellular carcinoma

We investigated the role of mitochondrial genetic alterations in hepatocellular carcinoma by directly comparing the mitochondrial genomes of 86 matched pairs of HCC and non-tumor liver samples. Substitutions in 637 mtDNA sites were detected, comprising 89.80% transitions and 6.60% transversions. For...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Qiao, Lihua, Ru, Guoqing, Mao, Zhuochao, Wang, Chenghui, Nie, Zhipeng, Li, Qiang, Huang-yang, Yiyi, Zhu, Ling, Liang, Xiaoyang, Yu, Jialing, Jiang, Pingping
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663603/
https://ncbi.nlm.nih.gov/pubmed/29137431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21033
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