Frequent Truncating Mutation of TFAM Induces Mitochondrial DNA Depletion and Apoptotic Resistance in Microsatellite-Unstable Colorectal Cancer

The mitochondrial transcription factor A (TFAM) is required for mitochondrial DNA (mtDNA) replication and transcription. Disruption of TFAM results in heart failure and premature aging in mice. But very little is known about the role of TFAM in cancer development. Here, we report the identification...

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Detalhes bibliográficos
Main Authors: Guo, Jianhui, Zheng, Li, Liu, Wenyong, Wang, Xianshu, Wang, Zemin, Wang, Zehua, French, Amy J., Kang, Dongchon, Chen, Lin, Thibodeau, Stephen N., Liu, Wanguo
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710668/
https://ncbi.nlm.nih.gov/pubmed/21467167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3482
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