Post-transcriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors

The majority of pancreatic ductal adenocarcinomas (PDA) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here we show that CRISPR-Cas9-mediated silencing of the HuR locus increases the relative sensitivity of PDA cells to PARP inhibitors (PARPi). PDA cells trea...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Chand, Saswati N., Zarei, Mahsa, Schiewer, Matthew J., Kamath, Akshay R., Romeo, Carmella, Lal, Shruti, Cozzitorto, Joseph A., Nevler, Avinoam, Scolaro, Laura, Londin, Eric, Jiang, Wei, Meisner-Kober, Nicole, Pishvaian, Michael J., Knudsen, Karen E., Yeo, Charles J., Pascal, John M., Winter, Jordan M., Brody, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663502/
https://ncbi.nlm.nih.gov/pubmed/28687616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2704
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