Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells

Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenvironment. Here we illustrate how such conditions promote chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC). Glucose or glutamine withdrawal resulted in a 5- to 10-fold protective effect...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Zarei, Mahsa, Lal, Shruti, Parker, Seth J., Nevler, Avinoam, Vaziri-Gohar, Ali, Dukleska, Katerina, Mambelli-Lisboa, Nicole C., Moffat, Cynthia, Blanco, Fernando F., Chand, Saswati N., Jimbo, Masaya, Cozzitorto, Joseph A., Jiang, Wei, Yeo, Charles J., Londin, Eric R., Seifert, Erin L., Metallo, Christian M., Brody, Jonathan R., Winter, Jordan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922269/
https://ncbi.nlm.nih.gov/pubmed/28652247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0015
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