CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer related deaths in the U.S., while colorectal cancer (CRC) is the third most common cancer. The RNA binding protein HuR (ELAVL1), supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR exp...

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Pubblicato in:Mol Cancer Res
Autori principali: Lal, Shruti, Cheung, Edwin C., Zarei, Mahsa, Preet, Ranjan, Chand, Saswati N., Mambelli-Lisboa, Nicole C., Romeo, Carmella, Stout, Matthew C., Londin, Eric, Goetz, Austin, Lowder, Cinthya Y., Nevler, Avinoam, Yeo, Charles J., Campbell, Paul M., Winter, Jordan M., Dixon, Dan A., Brody, Jonathan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466444/
https://ncbi.nlm.nih.gov/pubmed/28242812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0361
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