CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer related deaths in the U.S., while colorectal cancer (CRC) is the third most common cancer. The RNA binding protein HuR (ELAVL1), supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR exp...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Lal, Shruti, Cheung, Edwin C., Zarei, Mahsa, Preet, Ranjan, Chand, Saswati N., Mambelli-Lisboa, Nicole C., Romeo, Carmella, Stout, Matthew C., Londin, Eric, Goetz, Austin, Lowder, Cinthya Y., Nevler, Avinoam, Yeo, Charles J., Campbell, Paul M., Winter, Jordan M., Dixon, Dan A., Brody, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466444/
https://ncbi.nlm.nih.gov/pubmed/28242812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0361
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