CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer related deaths in the U.S., while colorectal cancer (CRC) is the third most common cancer. The RNA binding protein HuR (ELAVL1), supports a pro-oncogenic network in gastrointestinal (GI) cancer cells through enhanced HuR exp...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Res
Huvudupphovsmän: Lal, Shruti, Cheung, Edwin C., Zarei, Mahsa, Preet, Ranjan, Chand, Saswati N., Mambelli-Lisboa, Nicole C., Romeo, Carmella, Stout, Matthew C., Londin, Eric, Goetz, Austin, Lowder, Cinthya Y., Nevler, Avinoam, Yeo, Charles J., Campbell, Paul M., Winter, Jordan M., Dixon, Dan A., Brody, Jonathan R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466444/
https://ncbi.nlm.nih.gov/pubmed/28242812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0361
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