Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells

Akt1 through the C-terminal domain interacts with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and stimulates the repair of DNA double-strand breaks (DSBs) in K-RAS-mutated (K-RASmut) cells. We investigated the interactions of distinct domain(s) of DNA-PKcs in binding to full-length...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Toulany, Mahmoud, Maier, Julia, Iida, Mari, Rebholz, Simone, Holler, Marina, Grottke, Astrid, Jüker, Manfred, Wheeler, Deric L, Rothbauer, Ulrich, Rodemann, H Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661268/
https://ncbi.nlm.nih.gov/pubmed/29090098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.72
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