ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition

K-RAS mutated (K-RASmut) non-small cell lung cancer (NSCLC) cells are resistant to EGFR targeting strategies. We investigated the impact of K-RAS activity irrespective of mutational status in the EGFR-independent increase in clonogenic cell survival. An analysis of the K-RAS activity status revealed...

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Sonraí Bibleagrafaíochta
Main Authors: Toulany, Mahmoud, Minjgee, Minjmaa, Saki, Mohammad, Holler, Marina, Meier, Friedegund, Eicheler, Wolfgang, Rodemann, H Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2014
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974833/
https://ncbi.nlm.nih.gov/pubmed/24351425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.27311
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