Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer

Despite the significant contribution of radiotherapy to non-small lung cancer (NSCLC), radioresistance still occurs. One of the major radioresistance mechanisms is the hyperactivation of the PI3K/Akt pathway in which Akt facilitates the repair of DNA double-strand breaks (DSBs) through the stimulati...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Toulany, Mahmoud, Iida, Mari, Keinath, Simone, Iyi, Firdevs F., Mueck, Katharina, Fehrenbacher, Birgit, Mansour, Wael Y., Schaller, Martin, Wheeler, Deric L., Rodemann, H. Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190057/
https://ncbi.nlm.nih.gov/pubmed/27248324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9670
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