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CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels
In this study, we report that the tetraspanin CD81 enhances HIV-1 reverse transcription in HIV-1-infected cells. This is enabled by the direct interaction of CD81 with the deoxynucleoside triphosphate phosphohydrolase SAMHD1. This interaction prevents the endosomal accumulation and favours the prote...
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| Publicado no: | Nat Microbiol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5660623/ https://ncbi.nlm.nih.gov/pubmed/28871089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-017-0019-0 |
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