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How Germinal Centers Evolve Broadly Neutralizing Antibodies: the Breadth of the Follicular Helper T Cell Response

Many HIV-1-infected patients evolve broadly neutralizing antibodies (bnAbs). This evolutionary process typically takes several years and is poorly understood as selection taking place in germinal centers occurs on the basis of antibody affinity. B cells with the highest-affinity receptors tend to ac...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: De Boer, Rob J., Perelson, Alan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660473/
https://ncbi.nlm.nih.gov/pubmed/28878083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00983-17
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