Widespread brain distribution and activity following i.c.v. infusion of anti‐β‐secretase (BACE1) in nonhuman primates

BACKGROUND AND PURPOSE: The potential for therapeutic antibody treatment of neurological diseases is limited by poor penetration across the blood–brain barrier. I.c.v. delivery is a promising route to the brain; however, it is unclear how efficiently antibodies delivered i.c.v. penetrate the cerebro...

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Bibliografski detalji
Izdano u:Br J Pharmacol
Glavni autori: Yadav, Daniela Bumbaca, Maloney, Janice A, Wildsmith, Kristin R, Fuji, Reina N, Meilandt, William J, Solanoy, Hilda, Lu, Yanmei, Peng, Kun, Wilson, Blair, Chan, Pamela, Gadkar, Kapil, Kosky, Andrew, Goo, Marisa, Daugherty, Ann, Couch, Jessica A, Keene, Thomas, Hayes, Karen, Nikolas, Lisa Jungbauer, Lane, Deanna, Switzer, Robert, Adams, Eric, Watts, Ryan J, Scearce‐Levie, Kimberly, Prabhu, Saileta, Shafer, Lisa, Thakker, Deepak R, Hildebrand, Keith, Atwal, Jasvinder K
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659992/
https://ncbi.nlm.nih.gov/pubmed/28859225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14021
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