Widespread brain distribution and activity following i.c.v. infusion of anti‐β‐secretase (BACE1) in nonhuman primates

BACKGROUND AND PURPOSE: The potential for therapeutic antibody treatment of neurological diseases is limited by poor penetration across the blood–brain barrier. I.c.v. delivery is a promising route to the brain; however, it is unclear how efficiently antibodies delivered i.c.v. penetrate the cerebro...

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Publicado en:Br J Pharmacol
Main Authors: Yadav, Daniela Bumbaca, Maloney, Janice A, Wildsmith, Kristin R, Fuji, Reina N, Meilandt, William J, Solanoy, Hilda, Lu, Yanmei, Peng, Kun, Wilson, Blair, Chan, Pamela, Gadkar, Kapil, Kosky, Andrew, Goo, Marisa, Daugherty, Ann, Couch, Jessica A, Keene, Thomas, Hayes, Karen, Nikolas, Lisa Jungbauer, Lane, Deanna, Switzer, Robert, Adams, Eric, Watts, Ryan J, Scearce‐Levie, Kimberly, Prabhu, Saileta, Shafer, Lisa, Thakker, Deepak R, Hildebrand, Keith, Atwal, Jasvinder K
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659992/
https://ncbi.nlm.nih.gov/pubmed/28859225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14021
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