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DNA topology in chromatin is defined by nucleosome spacing

In eukaryotic nucleosomes, DNA makes ~1.7 superhelical turns around histone octamer. However, there is a long-standing discrepancy between the nucleosome core structure determined by x-ray crystallography and measurements of DNA topology in circular minichromosomes, indicating that there is only ~1....

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Publicat a:Sci Adv
Autors principals: Nikitina, Tatiana, Norouzi, Davood, Grigoryev, Sergei A., Zhurkin, Victor B.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659657/
https://ncbi.nlm.nih.gov/pubmed/29098179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1700957
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