A p53 super-tumor suppressor reveals a tumor suppressive p53-Ptpn14-Yap axis in pancreatic cancer

The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants. Surprisingly, t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Cell
Prif Awduron: Mello, Stephano S., Valente, Liz J., Raj, Nitin, Seoane, Jose A., Flowers, Brittany M., McClendon, Jacob, Bieging-Rolett, Kathryn T., Lee, Jonghyeob, Ivanochko, Danton, Kozak, Margaret M., Chang, Daniel T., Longacre, Teri A., Koong, Albert C., Arrowsmith, Cheryl H., Kim, Seung K., Vogel, Hannes, Wood, Laura D., Hruban, Ralph H., Curtis, Christina, Attardi, Laura D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659188/
https://ncbi.nlm.nih.gov/pubmed/29017057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.09.007
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