A p53 super-tumor suppressor reveals a tumor suppressive p53-Ptpn14-Yap axis in pancreatic cancer

The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants. Surprisingly, t...

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發表在:Cancer Cell
Main Authors: Mello, Stephano S., Valente, Liz J., Raj, Nitin, Seoane, Jose A., Flowers, Brittany M., McClendon, Jacob, Bieging-Rolett, Kathryn T., Lee, Jonghyeob, Ivanochko, Danton, Kozak, Margaret M., Chang, Daniel T., Longacre, Teri A., Koong, Albert C., Arrowsmith, Cheryl H., Kim, Seung K., Vogel, Hannes, Wood, Laura D., Hruban, Ralph H., Curtis, Christina, Attardi, Laura D.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659188/
https://ncbi.nlm.nih.gov/pubmed/29017057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.09.007
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