A p53 super-tumor suppressor reveals a tumor suppressive p53-Ptpn14-Yap axis in pancreatic cancer

The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants. Surprisingly, t...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer Cell
Autori principali: Mello, Stephano S., Valente, Liz J., Raj, Nitin, Seoane, Jose A., Flowers, Brittany M., McClendon, Jacob, Bieging-Rolett, Kathryn T., Lee, Jonghyeob, Ivanochko, Danton, Kozak, Margaret M., Chang, Daniel T., Longacre, Teri A., Koong, Albert C., Arrowsmith, Cheryl H., Kim, Seung K., Vogel, Hannes, Wood, Laura D., Hruban, Ralph H., Curtis, Christina, Attardi, Laura D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659188/
https://ncbi.nlm.nih.gov/pubmed/29017057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.09.007
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi